Smooth muscle–derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis

Resident vascular adventitial SCA1(+) progenitor (AdvSca1) cells are essential in vascular development and injury. However, the heterogeneity of AdvSca1 cells presents a unique challenge in understanding signaling pathways orchestrating their behavior in homeostasis and injury responses. Using smoot...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Lu, Sizhao, Jolly, Austin J., Strand, Keith A., Dubner, Allison M., Mutryn, Marie F., Moulton, Karen S., Nemenoff, Raphael A., Majesky, Mark W., Weiser-Evans, Mary C.M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714399/
https://ncbi.nlm.nih.gov/pubmed/33119549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139445
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