Pyridoxal-5′-Phosphate-Dependent Alkyl Transfer in Nucleoside Antibiotic Biosynthesis

Several nucleoside antibiotics are structurally characterized by a 5′′-amino-5′′-deoxyribose (ADR) appended via a glycosidic bond to a high-carbon sugar nucleoside, (5′S,6′S)-5′-C-glycyluridine (GlyU). GlyU is further modified with an N-alkylamine linker, the biosynthetic origins of which have yet t...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Cui, Zheng, Overbay, Jonathan, Wang, Xiachang, Liu, Xiaodong, Zhang, Yinan, Bhardwaj, Minakshi, Lemke, Anke, Wiegmann, Daniel, Niro, Giuliana, Thorson, Jon S., Ducho, Christian, Van Lanen, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7377962/
https://ncbi.nlm.nih.gov/pubmed/32483377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0548-3
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