Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order

Muraymycins are antibacterial natural products from Streptomyces spp. that inhibit translocase I (MraY), which is involved in cell wall biosynthesis. Structurally, muraymycins consist of a 5′-C-glycyluridine (GlyU) appended to a 5″-amino-5″-deoxyribose (ADR), forming a disaccharide core that is foun...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Cui, Zheng, Wang, Xia-Chang, Liu, Xiaodong, Lemke, Anke, Koppermann, Stefan, Ducho, Christian, Rohr, Jürgen, Thorson, Jon S., Van Lanen, Steven G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021665/
https://ncbi.nlm.nih.gov/pubmed/29735559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00193-18
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