Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis

Inflammatory bowel disease (IBD) represents a group of chronic relapsing intestinal disorders. Rutaecarpine (RUT), isolated from the Traditional Chinese Medicine (TCM) of Evodia rutaecarpa, was reported to suppress IBD. However, the mechanism by which RUT ameliorates dextran sulfate sodium (DSS)-ind...

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Détails bibliographiques
Publié dans:Free Radic Biol Med
Auteurs principaux: Zhang, Youbo, Yan, Tingting, Sun, Dongxue, Xie, Cen, Wang, Tianxia, Liu, Xiaoyan, Wang, Jing, Wang, Qiong, Luo, Yuhong, Wang, Ping, Yagai, Tomoki, Krausz, Kristopher W., Yang, Xiuwei, Gonzalez, Frank J.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376370/
https://ncbi.nlm.nih.gov/pubmed/31874248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.12.012
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