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Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis

Inflammatory bowel disease (IBD) represents a group of chronic relapsing intestinal disorders. Rutaecarpine (RUT), isolated from the Traditional Chinese Medicine (TCM) of Evodia rutaecarpa, was reported to suppress IBD. However, the mechanism by which RUT ameliorates dextran sulfate sodium (DSS)-ind...

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Bibliografiske detaljer
Udgivet i:Free Radic Biol Med
Main Authors: Zhang, Youbo, Yan, Tingting, Sun, Dongxue, Xie, Cen, Wang, Tianxia, Liu, Xiaoyan, Wang, Jing, Wang, Qiong, Luo, Yuhong, Wang, Ping, Yagai, Tomoki, Krausz, Kristopher W., Yang, Xiuwei, Gonzalez, Frank J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376370/
https://ncbi.nlm.nih.gov/pubmed/31874248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.12.012
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