Rutaecarpine inhibits KEAP1-NRF2 interaction to activate NRF2 and ameliorate dextran sulfate sodium-induced colitis

Inflammatory bowel disease (IBD) represents a group of chronic relapsing intestinal disorders. Rutaecarpine (RUT), isolated from the Traditional Chinese Medicine (TCM) of Evodia rutaecarpa, was reported to suppress IBD. However, the mechanism by which RUT ameliorates dextran sulfate sodium (DSS)-ind...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Zhang, Youbo, Yan, Tingting, Sun, Dongxue, Xie, Cen, Wang, Tianxia, Liu, Xiaoyan, Wang, Jing, Wang, Qiong, Luo, Yuhong, Wang, Ping, Yagai, Tomoki, Krausz, Kristopher W., Yang, Xiuwei, Gonzalez, Frank J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376370/
https://ncbi.nlm.nih.gov/pubmed/31874248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.12.012
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