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The Amphipathic GM1 Molecule Stabilizes Amyloid Aggregates, Preventing their Cytotoxicity

Amyloid aggregates have been demonstrated to exert cytotoxic effects in several diseases. It is widely accepted that the complex and fascinating aggregation pathway involves a series of steps during which many heterogeneous intermediates are generated. This process may be greatly potentiated by the...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Bucciantini, Monica, Leri, Manuela, Stefani, Massimo, Melki, Ronald, Zecchi-Orlandini, Sandra, Nosi, Daniele
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376221/
https://ncbi.nlm.nih.gov/pubmed/32579964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.06.005
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