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Energetics of Flap Opening in HIV-1 Protease: String Method Calculations
HIV-1 protease (PR) is the viral protein responsible for virion maturation, and its mechanisms of action remain incompletely understood. PR is dimeric and contains two flexible, symmetry-related flaps which act as a gate to inhibit access to the binding pocket and hold the polypeptide substrate in t...
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| Published in: | J Phys Chem B |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7375464/ https://ncbi.nlm.nih.gov/pubmed/31640343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.9b08348 |
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