Chargement en cours...
HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations
We report unrestrained, all-atom molecular dynamics simulations of HIV-1 protease that sample large conformational changes of the active site flaps. In particular, the unliganded protease undergoes multiple conversions between the “closed” and “semiopen” forms observed in crystal structures of inhib...
Enregistré dans:
| Auteurs principaux: | , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2006
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1347991/ https://ncbi.nlm.nih.gov/pubmed/16418268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508452103 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|