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Targeting structural flexibility in HIV-1 protease inhibitor binding
HIV-1 protease remains an important AIDS drug target. Even though it has been known that ligand binding induces large conformational changes in the protease, the dynamic aspects of binding have been largely ignored. Several computational models describing protease dynamics have been reported recentl...
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| Veröffentlicht in: | Drug Discov Today |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4767006/ https://ncbi.nlm.nih.gov/pubmed/17275733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2006.12.011 |
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