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Targeting structural flexibility in HIV-1 protease inhibitor binding

HIV-1 protease remains an important AIDS drug target. Even though it has been known that ligand binding induces large conformational changes in the protease, the dynamic aspects of binding have been largely ignored. Several computational models describing protease dynamics have been reported recentl...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Drug Discov Today
Prif Awduron: Hornak, Viktor, Simmerling, Carlos
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767006/
https://ncbi.nlm.nih.gov/pubmed/17275733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2006.12.011
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