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Structures of Darunavir-Resistant HIV-1 Protease Mutant Reveal Atypical Binding of Darunavir to Wide Open Flaps
[Image: see text] The molecular basis for high resistance to clinical inhibitors of HIV-1 protease (PR) was examined for the variant designated PR(P51) that was selected for resistance to darunavir (DRV). High resolution crystal structures of PR(P51) with the active site D25N mutation revealed a lig...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4076034/ https://ncbi.nlm.nih.gov/pubmed/24738918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4008875 |
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