Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

AIMS: The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF. METHODS AND RESULTS: C7 w...

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Опубликовано в: :ESC Heart Fail
Главные авторы: Ciccarelli, Michele, Sorriento, Daniela, Fiordelisi, Antonella, Gambardella, Jessica, Franco, Antonietta, del Giudice, Carmine, Sala, Marina, Monti, Maria Gaia, Bertamino, Alessia, Campiglia, Pietro, Oliveti, Marco, Poggio, Paolo, Trinchese, Giovanna, Cavaliere, Gina, Cipolletta, Ersilia, Mollica, Maria Pina, Bonaduce, Domenico, Trimarco, Bruno, Iaccarino, Guido
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
Предметы:
Original Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373898/
https://ncbi.nlm.nih.gov/pubmed/32352228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12706
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