Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

AIMS: The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF. METHODS AND RESULTS: C7 w...

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Detalhes bibliográficos
Publicado no:ESC Heart Fail
Main Authors: Ciccarelli, Michele, Sorriento, Daniela, Fiordelisi, Antonella, Gambardella, Jessica, Franco, Antonietta, del Giudice, Carmine, Sala, Marina, Monti, Maria Gaia, Bertamino, Alessia, Campiglia, Pietro, Oliveti, Marco, Poggio, Paolo, Trinchese, Giovanna, Cavaliere, Gina, Cipolletta, Ersilia, Mollica, Maria Pina, Bonaduce, Domenico, Trimarco, Bruno, Iaccarino, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373898/
https://ncbi.nlm.nih.gov/pubmed/32352228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.12706
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