Endothelial GRK2 regulates vascular homeostasis through the control of free radical oxygen species

OBJECTIVE: The role of endothelial GRK2 was investigated in mice with selective deletion of the kinase in the endothelium (Tie2-CRE/GRK2(fl/fl)). APPROACH AND RESULTS: Aortas from Tie2-CRE/GRK2(fl/fl) presented functional and structural alterations as compared to control GRK2(fl/fl) mice. In particu...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Ciccarelli, Michele, Sorriento, Daniela, Franco, Antonietta, Fusco, Anna, Giudice, Carmine Del, Annunziata, Roberto, Cipolletta, Ersilia, Monti, Maria Gaia, Dorn, Gerald W, Trimarco, Bruno, Iaccarino, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262246/
https://ncbi.nlm.nih.gov/pubmed/23950144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.302262
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