Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse

There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Towar...

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Vydáno v:Front Genet
Hlavní autoři: Machado, Thiago S., Macabelli, Carolina H., Collado, Maite Del, Meirelles, Flávio V., Guimarães, Francisco E. G., Chiaratti, Marcos R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373801/
https://ncbi.nlm.nih.gov/pubmed/32760430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00762
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