Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse

There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Towar...

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Foilsithe in:Front Genet
Main Authors: Machado, Thiago S., Macabelli, Carolina H., Collado, Maite Del, Meirelles, Flávio V., Guimarães, Francisco E. G., Chiaratti, Marcos R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Genetics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373801/
https://ncbi.nlm.nih.gov/pubmed/32760430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00762
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