Evidence of Selection Against Damaged Mitochondria During Early Embryogenesis in the Mouse

There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Towar...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Genet
Egile Nagusiak: Machado, Thiago S., Macabelli, Carolina H., Collado, Maite Del, Meirelles, Flávio V., Guimarães, Francisco E. G., Chiaratti, Marcos R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Genetics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373801/
https://ncbi.nlm.nih.gov/pubmed/32760430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00762
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