Asymmetric Total Synthesis of Mycobacterial Diacyl Trehaloses Demonstrates a Role for Lipid Structure in Immunogenicity

[Image: see text] The first asymmetric total synthesis of three structures proposed for mycobacterial diacyl trehaloses, DAT(1), DAT(2), and DAT(3) is reported. The presence of two of these glycolipids, DAT(1) and DAT(3), within different strains of pathogenic M. tuberculosis was confirmed, and it w...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Holzheimer, Mira, Reijneveld, Josephine F., Ramnarine, Alexandrea K., Misiakos, Georgios, Young, David C., Ishikawa, Eri, Cheng, Tan-Yun, Yamasaki, Sho, Moody, D. Branch, Van Rhijn, Ildiko, Minnaard, Adriaan J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372558/
https://ncbi.nlm.nih.gov/pubmed/32293864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00030
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