Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of mycobacterial diacyltrehalose (DAT) that differ...

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Udgivet i:Sci Rep
Main Authors: Reijneveld, Josephine F., Holzheimer, Mira, Young, David C., Lopez, Kattya, Suliman, Sara, Jimenez, Judith, Calderon, Roger, Lecca, Leonid, Murray, Megan B., Ishikawa, Eri, Yamasaki, Sho, Minnaard, Adriaan J., Moody, D. Branch, Van Rhijn, Ildiko
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820438/
https://ncbi.nlm.nih.gov/pubmed/33479373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81474-3
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