Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of mycobacterial diacyltrehalose (DAT) that differ...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Reijneveld, Josephine F., Holzheimer, Mira, Young, David C., Lopez, Kattya, Suliman, Sara, Jimenez, Judith, Calderon, Roger, Lecca, Leonid, Murray, Megan B., Ishikawa, Eri, Yamasaki, Sho, Minnaard, Adriaan J., Moody, D. Branch, Van Rhijn, Ildiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820438/
https://ncbi.nlm.nih.gov/pubmed/33479373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81474-3
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