Proteome activity landscapes of tumor cell lines determine drug responses

Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer cell lines (CCLs) is an emerging approach to uncover molecular mechanisms of drug action. We extend this paradigm to measuring proteome activity landscapes by acquiring and integrating quantitative data for 10,000...

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Published in:Nat Commun
Main Authors: Frejno, Martin, Meng, Chen, Ruprecht, Benjamin, Oellerich, Thomas, Scheich, Sebastian, Kleigrewe, Karin, Drecoll, Enken, Samaras, Patroklos, Hogrebe, Alexander, Helm, Dominic, Mergner, Julia, Zecha, Jana, Heinzlmeir, Stephanie, Wilhelm, Mathias, Dorn, Julia, Kvasnicka, Hans-Michael, Serve, Hubert, Weichert, Wilko, Kuster, Bernhard
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371697/
https://ncbi.nlm.nih.gov/pubmed/32686665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17336-9
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