Proteome activity landscapes of tumor cell lines determine drug responses

Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer cell lines (CCLs) is an emerging approach to uncover molecular mechanisms of drug action. We extend this paradigm to measuring proteome activity landscapes by acquiring and integrating quantitative data for 10,000...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Frejno, Martin, Meng, Chen, Ruprecht, Benjamin, Oellerich, Thomas, Scheich, Sebastian, Kleigrewe, Karin, Drecoll, Enken, Samaras, Patroklos, Hogrebe, Alexander, Helm, Dominic, Mergner, Julia, Zecha, Jana, Heinzlmeir, Stephanie, Wilhelm, Mathias, Dorn, Julia, Kvasnicka, Hans-Michael, Serve, Hubert, Weichert, Wilko, Kuster, Bernhard
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371697/
https://ncbi.nlm.nih.gov/pubmed/32686665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17336-9
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