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Comparison of hierarchical EMAX and NDLM models in dose-response for early phase clinical trials
BACKGROUND: Phase II clinical trials primarily aim to find the optimal dose and investigate the relationship between dose and efficacy relative to standard of care (control). Therefore, before moving forward to a phase III confirmatory trial, the most effective dose is needed to be identified. METHO...
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| Publicado no: | BMC Med Res Methodol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7370408/ https://ncbi.nlm.nih.gov/pubmed/32690004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-020-01071-2 |
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