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Myopathic changes associated with psychomotor delay and seizures caused by a novel homozygous mutation in TBCK

INTRODUCTION: Biallelic mutations in TBC1-domain containing kinase (TBCK) lead to hypotonia, global developmental delay with severe cognitive and motor deficits, and variable presentation of dysmorphic facial features and brain malformations. It remains unclear whether hypotonia in these individuals...

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Publicado en:Muscle Nerve
Main Authors: Saredi, Simona, Cauley, Edmund S., Ruggieri, Alessandra, Spivey, Tyler M., Ardissone, Anna, Mora, Marina, Moroni, Isabella, Manzini, M. Chiara
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7369155/
https://ncbi.nlm.nih.gov/pubmed/32363625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mus.26907
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