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Regulation and Consequences of cGAS Activation by Self-DNA
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a major responder to the pathogenic DNA of viruses and bacteria. Upon DNA binding, cGAS becomes enzymatically active to generate the second messenger cGAMP, leading to activation of inflammatory genes, type I interferon production, autophagy and cell death....
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| Publicado no: | Trends Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7368801/ https://ncbi.nlm.nih.gov/pubmed/32546434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2020.05.006 |
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