A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation

Master splicing regulator MBNL1 shapes large transcriptomic changes that drive cellular differentiation during development. Here we demonstrate that MBNL1 is a suppressor of tumor dedifferentiation. We surveyed MBNL1 expression in matched tumor/normal pairs across The Cancer Genome Atlas and found t...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ray, Debleena, Yun, Yu Chye, Idris, Muhammad, Cheng, Shanshan, Boot, Arnoud, Iain, Tan Bee Huat, Rozen, Steven G., Tan, Patrick, Epstein, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368273/
https://ncbi.nlm.nih.gov/pubmed/32601196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002499117
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados