MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

TRIM family proteins play integral roles in the innate immune response to virus infection. MG53 (TRIM72) is essential for cell membrane repair and is believed to be a muscle-specific TRIM protein. Here we show human macrophages express MG53, and MG53 protein expression is reduced following virus inf...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sermersheim, Matthew, Kenney, Adam D., Lin, Pei-Hui, McMichael, Temet M., Cai, Chuanxi, Gumpper, Kristyn, Adesanya, T. M. Ayodele, Li, Haichang, Zhou, Xinyu, Park, Ki-Ho, Yount, Jacob S., Ma, Jianjie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368064/
https://ncbi.nlm.nih.gov/pubmed/32681036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17177-6
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