Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show that MG53 present in blood circulation acts as a myokine to facilitate tissue injury-repair and regeneration. Transgenic mice with sustained elevation of MG53 in the bloodstream (tPA-MG5...

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Vydáno v:Nat Commun
Hlavní autoři: Bian, Zehua, Wang, Qiang, Zhou, Xinyu, Tan, Tao, Park, Ki Ho, Kramer, H. Fritz, McDougal, Alan, Laping, Nicholas J., Kumar, Sanjay, Adesanya, T. M. Ayodele, Sermersheim, Matthew, Yi, Frank, Wang, Xinxin, Wu, Junwei, Gumpper, Kristyn, Jiang, Qiwei, He, Duofen, Lin, Pei-Hui, Li, Haichang, Guan, Fangxia, Zhou, Jingsong, Kohr, Mark J., Zeng, Chunyu, Zhu, Hua, Ma, Jianjie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789113/
https://ncbi.nlm.nih.gov/pubmed/31604915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12483-0
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