Argonaute binding within 3′-untranslated regions poorly predicts gene repression

Despite two decades of study, the full scope of RNAi in mammalian cells has remained obscure. Here we combine: (i) Knockout of argonaute (AGO) variants; (ii) RNA sequencing analysis of gene expression changes and (iii) Enhanced Crosslinking Immunoprecipitation Sequencing (eCLIP-seq) using anti-AGO2...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Chu, Yongjun, Kilikevicius, Audrius, Liu, Jing, Johnson, Krystal C, Yokota, Shinnichi, Corey, David R
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
RNA and RNA-protein complexes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7367155/
https://ncbi.nlm.nih.gov/pubmed/32501500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa478
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