RNA-binding protein DDX1 is responsible for fatty acid-mediated repression of insulin translation

The molecular mechanism in pancreatic β cells underlying hyperlipidemia and insulin insufficiency remains unclear. Here, we find that the fatty acid-induced decrease in insulin levels occurs due to a decrease in insulin translation. Since regulation at the translational level is generally mediated t...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Li, Zonghong, Zhou, Maoge, Cai, Zhaokui, Liu, Hongyang, Zhong, Wen, Hao, Qiang, Cheng, Dongwan, Hu, Xihao, Hou, Junjie, Xu, Pingyong, Xue, Yuanchao, Zhou, Yifa, Xu, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294501/
https://ncbi.nlm.nih.gov/pubmed/30295850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky867
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