Muscle NAD(+) depletion and Serpina3n as molecular determinants of murine cancer cachexia—the effects of blocking myostatin and activins

OBJECTIVE: Cancer cachexia and muscle loss are associated with increased morbidity and mortality. In preclinical animal models, blocking activin receptor (ACVR) ligands has improved survival and prevented muscle wasting in cancer cachexia without an effect on tumour growth. However, the underlying m...

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Dades bibliogràfiques
Publicat a:Mol Metab
Autors principals: Hulmi, J.J., Penna, F., Pöllänen, N., Nissinen, T.A., Hentilä, J., Euro, L., Lautaoja, J.H., Ballarò, R., Soliymani, R., Baumann, M., Ritvos, O., Pirinen, E., Lalowski, M.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7364159/
https://ncbi.nlm.nih.gov/pubmed/32599075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101046
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