Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

BACKGROUND: Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. However, the underlying mechanisms have not yet been fully uncovered. METHODS: The effects of blocking activin receptor type 2 (ACVR2) ligands on both...

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Detalhes bibliográficos
Publicado no:J Cachexia Sarcopenia Muscle
Main Authors: Nissinen, Tuuli A., Hentilä, Jaakko, Penna, Fabio, Lampinen, Anita, Lautaoja, Juulia H., Fachada, Vasco, Holopainen, Tanja, Ritvos, Olli, Kivelä, Riikka, Hulmi, Juha J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989872/
https://ncbi.nlm.nih.gov/pubmed/29722201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12310
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