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Driver Mutations in Leukemia Promote Disease Pathogenesis through a Combination of Cell-Autonomous and Niche Modulation

Studies of patients with acute myeloid leukemia (AML) have led to the identification of mutations that affect different cellular pathways. Some of these have been classified as preleukemic, and a stepwise evolution program whereby cells acquire additional mutations has been proposed in the developme...

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Publicado en:Stem Cell Reports
Autores principales: Ramdas, Baskar, Mali, Raghuveer Singh, Palam, Lakshmi Reddy, Pandey, Ruchi, Cai, Zhigang, Pasupuleti, Santhosh Kumar, Burns, Sarah S., Kapur, Reuben
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363747/
https://ncbi.nlm.nih.gov/pubmed/32502465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.05.002
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