S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance

Hyperactivation of the mTOR pathway impairs hematopoietic stem cell (HSC) functions and promotes leukemogenesis. mTORC1 and mTORC2 differentially control normal and leukemic stem cell functions. mTORC1 regulates p70 ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E–binding (eI...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ghosh, Joydeep, Kobayashi, Michihiro, Ramdas, Baskar, Chatterjee, Anindya, Ma, Peilin, Mali, Raghuveer Singh, Carlesso, Nadia, Liu, Yan, Plas, David R., Chan, Rebecca J., Kapur, Reuben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922705/
https://ncbi.nlm.nih.gov/pubmed/27294524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84565
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