Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation

Phenotypes of haploid embryonic stem cells (haESCs) are dominant for recessive traits in mice. However, one major obstacle to their use is self-diploidization in daily culture. Although haESCs maintain haploidy well by deleting p53, whether they can sustain haploidy in differentiated status and the...

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Gepubliceerd in:Stem Cell Reports
Hoofdauteurs: Zhang, Wenhao, Tian, Yaru, Gao, Qian, Li, Xu, Li, Yanni, Zhang, Jinxin, Yao, Chunmeng, Wang, Yuna, Wang, Haoyu, Zhao, Yiding, Zhang, Qian, Li, Luyuan, Yu, Yang, Fan, Yong, Shuai, Ling
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363743/
https://ncbi.nlm.nih.gov/pubmed/32502463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.05.004
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