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The X to Autosome Expression Ratio in Haploid and Diploid Human Embryonic Stem Cells

Ohno proposed that the expression levels of X-linked genes have been doubled to compensate the degeneration of Y-linked homologs during the evolution of mammalian sex chromosomes, but RNA sequencing in human somatic tissues showed no such upregulation for the vast majority of X-linked genes. Here we...

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Pubblicato in:Mol Biol Evol
Autori principali: Chen, Xiaoshu, Zhang, Jianzhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100046/
https://ncbi.nlm.nih.gov/pubmed/27593371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw187
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