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Antimalarial Trioxolanes with Superior Drug-Like Properties and In vivo Efficacy

The emergence of artemisinin resistance, combined with certain sub-optimal properties of ozonide agents arterolane and artefenomel has necessitated the search for new drug candidates in the endoperoxide class. Our group has focused on trioxolane analogs with substitution patterns not previously expl...

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Foilsithe in:ACS Infect Dis
Main Authors: Blank, Brian R., Gonciarz, Ryan L., Talukder, Poulami, Gut, Jiri, Legac, Jennifer, Rosenthal, Philip J., Renslo, Adam R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363035/
https://ncbi.nlm.nih.gov/pubmed/32369341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.0c00064
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