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Drug Delivery to the Malaria Parasite Using an Arterolane-Like Scaffold
The antimalarial agents artemisinin and arterolane act via initial reduction of a peroxide bond in a process likely mediated by ferrous iron sources in the parasite. Here, we report the synthesis and antiplasmodial activity of arterolane-like 1,2,4-trioxolanes specifically designed to release a teth...
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| Publicado no: | ChemMedChem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4420023/ https://ncbi.nlm.nih.gov/pubmed/25314098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402362 |
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