Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core

Disruption of cyclophilin A (CypA)-capsid interactions affects HIV-1 replication in human lymphocytes. To understand this mechanism, we utilize human Jurkat cells, peripheral blood mononuclear cells (PBMCs), and CD4(+) T cells. Our results show that inhibition of HIV-1 infection caused by disrupting...

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Pubblicato in:Cell Rep
Autori principali: Selyutina, Anastasia, Persaud, Mirjana, Simons, Lacy M., Bulnes-Ramos, Angel, Buffone, Cindy, Martinez-Lopez, Alicia, Scoca, Viviana, Di Nunzio, Francesca, Hiatt, Joseph, Marson, Alexander, Krogan, Nevan J., Hultquist, Judd F., Diaz-Griffero, Felipe
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7363000/
https://ncbi.nlm.nih.gov/pubmed/32187548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.100
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