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Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core
Disruption of cyclophilin A (CypA)-capsid interactions affects HIV-1 replication in human lymphocytes. To understand this mechanism, we utilize human Jurkat cells, peripheral blood mononuclear cells (PBMCs), and CD4(+) T cells. Our results show that inhibition of HIV-1 infection caused by disrupting...
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| Опубликовано в: : | Cell Rep |
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| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7363000/ https://ncbi.nlm.nih.gov/pubmed/32187548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.100 |
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