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Protein Aggregation and Immunogenicity of Biotherapeutics

Recombinant proteins are the mainstay of biopharmaceuticals. A key challenge in the manufacturing and formulation of protein biologic products is the tendency for the active pharmaceutical ingredients to aggregate, resulting in irreversible drug loss, and an increase in immunogenicity risk. While th...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Int J Pharm
Päätekijät: Pham, Ngoc B., Meng, Wilson S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362938/
https://ncbi.nlm.nih.gov/pubmed/32531452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2020.119523
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