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Protein Aggregation and Immunogenicity of Biotherapeutics

Recombinant proteins are the mainstay of biopharmaceuticals. A key challenge in the manufacturing and formulation of protein biologic products is the tendency for the active pharmaceutical ingredients to aggregate, resulting in irreversible drug loss, and an increase in immunogenicity risk. While th...

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Detalhes bibliográficos
Publicado no:Int J Pharm
Main Authors: Pham, Ngoc B., Meng, Wilson S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362938/
https://ncbi.nlm.nih.gov/pubmed/32531452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2020.119523
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