Metastable HIV-1 Surface Protein Env Sensitizes Cell Membranes to Transformation and Poration by Dual-Acting Virucidal Entry Inhibitors

Dual-acting virucidal entry inhibitors (DAVEIs) have previously been shown to cause irreversible inactivation of HIV-1 Env-presenting pseudovirus by lytic membrane transformation. This study examined whether this transformation could be generalized to include membranes of Env-presenting cells. Flow...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Ang, Charles G., Hossain, Md. Alamgir, Rajpara, Marg, Bach, Harry, Acharya, Kriti, Dick, Alexej, Rashad, Adel A., Kutzler, Michele, Abrams, Cameron F., Chaiken, Irwin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362902/
https://ncbi.nlm.nih.gov/pubmed/31942789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b01008
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