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Reconstitution and substrate specificity of the thioether-forming radical S-adenosylmethionine enzyme in freyrasin biosynthesis

The radical non-α-carbon thioether peptides (ranthipeptides) are a newly described class of ribosomally synthesized and post-translationally modified peptide (RiPP). Ranthipeptide biosynthetic gene clusters are characterized by a Cys-rich precursor peptide and a radical S-adenosylmethionine (rSAM)-d...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Precord, Timothy W., Mahanta, Nilkamal, Mitchell, Douglas A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362900/
https://ncbi.nlm.nih.gov/pubmed/31449382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00457
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