Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological a...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Nebigil, Canan G., Moog, Christiane, Vagner, Stéphan, Benkirane-Jessel, Nadia, Smith, Duncan R., Désaubry, Laurent
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Masson SAS. 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362831/
https://ncbi.nlm.nih.gov/pubmed/32693294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112653
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