Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Eur J Med Chem
Prif Awduron: Nebigil, Canan G., Moog, Christiane, Vagner, Stéphan, Benkirane-Jessel, Nadia, Smith, Duncan R., Désaubry, Laurent
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Masson SAS. 2020
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362831/
https://ncbi.nlm.nih.gov/pubmed/32693294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112653
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