FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity

AIMS: The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties. A synthetic analog of flavaglines, FL3, efficiently protects mice from the cardiotoxicity of doxorubi...

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Publicat a:PLoS One
Autors principals: Qureshi, Rehana, Yildirim, Onur, Gasser, Adeline, Basmadjian, Christine, Zhao, Qian, Wilmet, Jean-Philippe, Désaubry, Laurent, Nebigil, Canan G.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633129/
https://ncbi.nlm.nih.gov/pubmed/26536361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141826
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