Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological a...

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Pubblicato in:Eur J Med Chem
Autori principali: Nebigil, Canan G., Moog, Christiane, Vagner, Stéphan, Benkirane-Jessel, Nadia, Smith, Duncan R., Désaubry, Laurent
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Masson SAS. 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362831/
https://ncbi.nlm.nih.gov/pubmed/32693294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112653
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