Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological a...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Nebigil, Canan G., Moog, Christiane, Vagner, Stéphan, Benkirane-Jessel, Nadia, Smith, Duncan R., Désaubry, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Masson SAS. 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362831/
https://ncbi.nlm.nih.gov/pubmed/32693294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112653
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