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A New Class of Antiretroviral Enabling Innate Immunity by Protecting APOBEC3 from HIV Vif-Dependent Degradation
The infectivity of the human immunodeficiency virus (HIV) depends on overcoming APOBEC3 (A3) innate immunity and does so predominantly through the expression of the viral protein, Vif, which induces A3 degradation in the proteasome. Disruption of the functional interactions of Vif enables A3 mutagen...
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| Publicado no: | Trends Mol Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7362305/ https://ncbi.nlm.nih.gov/pubmed/29609878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2018.03.004 |
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