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Determinants of Efficient Degradation of APOBEC3 Restriction Factors by HIV-1 Vif
The APOBEC3 deoxycytidine deaminases can restrict the replication of HIV-1 in cell culture to differing degrees. The effects of APOBEC3 enzymes are largely suppressed by HIV-1 Vif that interacts with host proteins to form a Cullin5-Ring E3 ubiquitin ligase that induces (48)K-linked polyubiquitinatio...
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| Publicado en: | J Virol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4249154/ https://ncbi.nlm.nih.gov/pubmed/25275135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02484-14 |
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