A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability

The Mre11-Rad50-Nbs1 complex is a DNA doublestrand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model, we d...

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Publicat a:Cell Rep
Autors principals: Fagan-Solis, Katerina D., Simpson, Dennis A., Kumar, Rashmi J., Martelotto, Luciano G., Mose, Lisle E., Rashid, Naim U., Ho, Alice Y., Powell, Simon N., Wen, Y. Hannah, Parker, Joel S., Reis-Filho, Jorge S., Petrini, John H.J., Gupta, Gaorav P.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7361372/
https://ncbi.nlm.nih.gov/pubmed/32023457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.020
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