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A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability
The Mre11-Rad50-Nbs1 complex is a DNA doublestrand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducible primary mammary epithelial cell model, we d...
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| Publié dans: | Cell Rep |
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| Auteurs principaux: | , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7361372/ https://ncbi.nlm.nih.gov/pubmed/32023457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.01.020 |
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